ALLODX
Complement Testing
Blood, urine sC5b-9, C5a, C3, FB, C3NeF, FH, anti-FH Ab, FI, Ba, C3a and other complement-related directions. Specific sample types and indicator combinations are confirmed by project.
COMPLEMENT PATHWAYS
In the complement pathway, find where to detect
The three activation pathways converge at C3 and C5, and then enter the terminal pathway. The turquoise “test” mark corresponds to AlloDx’s complement-related test items.
Open large image ↗View inspection items and access locations
- C3、FB：Complement component; FB participates in alternative C3 convertase formation.
- C3a、C5a、Ba：Corresponding to the activated fragments produced by C3, C5, and FB cleavage, respectively.
- C3NeF：Autoantibodies associated with the stability of alternative C3 convertase.
- FH、FI、anti-FH Ab：Regulators of alternative pathways and anti-FH autoantibodies.
- sC5b-9：Soluble terminal complement complex, with blood and urine related testing items.
Please confirm with the AlloDx technical team for the sample requirements, testing methods and combinations of each project.
Path reference:Reactome · Bypass activation、complement regulation、terminal pathway. Test items are organized based on AlloDx’s existing pages.
Products and research materials
Understand the latest developments in complement detection reagents and technologies that have been disclosed.
Soluble C5b-9 Assay Kit
Soluble C5b-9 detection: insight into complement activation and precise protection of every immune response. What traces will complement activation leave? In the final stage of complement activation, C5b, C6, C7, C8 and multiple C9s assemble into the membrane attack complex (MAC), which aggregates to form pores on the cell membrane. And when…
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AlloDx CompliNeF™ Assay: Reading C3NeF Function Through Bb Retention
AlloDx CompliNeF™ Assay: Readout of C3NeF function from Bb retention - A reliable C3NeF assay must reflect functional changes in C3 convertase while minimizing interference from anti-IgG signals. If…
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AlloDx launches CompliTCC™ sC5b-9 test
AlloDx launches CompliTCC™ sC5b-9 test
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Biomarker Insights: Why Is C3NeF Difficult to Measure Accurately?
C3NeF is one of the functional drivers of abnormal activation of the alternative complement pathway. The key to measuring it accurately lies in whether the functional status of the invertase can be…
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Biomarker Insights: Which Monoclonal Antibodies Can Accurately Measure sC5b-9?
AlloDx CompliTCC™ is based on independently developed AD99 and improves selectivity for complete sC5b-9 complexes from the antibody epitope level.
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Why Is sC5b-9 Difficult to Measure Accurately?
The complement system has three entrances but only one common terminal exit. The classical pathway, the lectin pathway, and the alternative pathway can be initiated by different triggers, but…
Read more ↗Soluble C5b-9 Assay Kit · Video Explanation
Discuss Your Project
Please confirm with the AlloDx technical team for sample requirements, testing scope, project cycle and report content.
Contact AlloDx ↗Some original figures, videos and downloadable materials are provided in Chinese.